Correlation of Tacrolimus Blood Concentration and Cystatin C in the Patients with Renal Transplantation
- VernacularTitle:他克莫司血药浓度与胱抑素C在肾移植受者中的相关性分析
- Author:
Yan JIANG
;
Sulan ZOU
;
Rong CHEN
;
Ping WU
;
Xianlin XU
;
Qingbo JIANG
- Keywords:
Renal transplantation;
Tacrolimus;
Drug concentration;
Serum cystatin C;
Serum creatinine
- From:
China Pharmacist
2017;20(3):488-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of the blood concentration of tacrolimus ( Tac) and serum cystatin C ( SCysC) and serum creatinine (Scr) in the patients with renal transplantation. Methods:Totally 84 cases of renal transplantation patients (67 male/17 female) treated with Tac were involved. The blood concentration of Tac, SCysC and Scr were monitored after the operation. Data results were categorized according to the postoperative time and the blood concentration. The correlations of Tac blood concentra-tion,SCysC and Scr were analyzed and compared by using Pearson correlation analysis. Results: The blood concentration of Tac was not significantly associated with SCysC and Scr in different postoperative time groups and different drug concentration groups ( P >0. 05). As the extension of time,the blood concentration of Tac showed a gradual declining trend, while SCysC and Scr levels de-creased first, and then increased gradually after two years of the operation. Conclusion:The blood concentration of Tac has no effect on the function evaluation of transplanted kidney by the biochemical indicators such as SCysC and Scr.
