Improvement of Forming Process of Jingning Particle
- VernacularTitle:经宁颗粒成型工艺的改进
- Author:
Xia YAN
;
Yajun CAO
;
Fengming NIU
- Keywords:
Jingning particle;
Preparation technology;
Hygroscopicity;
Dissolubility;
Pellet formation rate
- From:
China Pharmacist
2017;20(3):577-579
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the forming process of Jingning particle according to the influencing factors in its effectiveness, such as low yield, high moisture absorption and difficult dissolubility during oral administration. Methods:A new technology that im-mediate granulation after the extract was well mixed with lactose and dextrin and dried. The appearance, dissolubility, hygroscopicity and pellet formation rate ( granularity) were compared between the new technology and the old one, and the difference in critical rela-tive humidity was also studied. Results:The appearance, dissolubility and pellet formation rate of the new technology were all better than those of the old one, and the moisture absorption rate was reduced with the critical relative humidity up to 70%(25℃), which enhanced the granule stability. Conclusion:The pellet formation rate is improved by the new technology, which effectively solves the problems such as high moisture absorption and poor dissolubility, and the granule quality is improved.
