Simultaneous Determination of 8 Heavy Metal Elements in Iron Dextran by ICP-OES
- VernacularTitle:ICP-OES法同时测定右旋糖酐铁中铅、镉、砷、汞等8种重金属元素的含量
- Author:
Chao MA
;
Simeng FANG
;
Nan MI
;
Mujun SU
;
Yunlei ZHANG
- Keywords:
Inductively coupled plasma optical emission spectrometry;
Iron dextran;
Heavy metal elements
- From:
China Pharmacist
2017;20(3):579-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for the simultaneous determination of 8 heavy metal elements Pb, Cd, As, Hg, Co, V, Se and Mo in iron dextran by inductively coupled plasma optical emission spectrometry ( ICP-OES) . Methods:Through the detec-tion wavelength selection,the detection wavelength was confirmed as follows:220. 353 nm for Pb, 228. 802 nm for Cd, 188. 980 nm for As, 194. 164 nm for Hg, 228. 615 nm for Co, 311. 070 nm for V, 196. 026 nm for Se and 204. 598 nm for Mo. Through optimizing the instrument parameters, the optimal radio frequency power was 1. 3 kW, the nebulizer gas flow rate was 0. 7 L·min-1, and the pump speed was 10 r·min-1. By applying the above detection parameters, the 8 heavy metal elements were analyzed by ICP-OES simultaneously. Results: The linearity of the detected elements was good, and the correlation coefficients were all greater than 0. 9990. The detection limits were from 0. 12 to 7. 26 ng·ml-1 , the quantitation limits were from 0. 40 to 23. 96 ng·ml-1 and the recoveries were from 94. 1% to 103. 4% (RSD<3%, n=9). Conclusion: The method is specific, sensitive, rapid and accurate, which can be applied in the simultaneous determination of 8 heavy metal elements in iron dextran.
