Distribution of Astrocytic Syntrophin in Hippocampus from Human Mesial Temporal Lobe Epilepsy

VernacularTitle:人颞叶内侧癫痫海马组织星形胶质细胞Syntrophin的表达变化
Author: Xiaoxuan WANG ; Zhenrong SUN ; Min WU ; Zhongfang SHI ; Xu YAN ; Lixin XU ; Liping DONG ; Shaohua YANG ; Fang YUAN
Keywords: mesial temporal lobe epilepsy; hippocampus; astrocyte; syntrophin; dystrophin-associated glycoprotein complex
From: Chinese Journal of Rehabilitation Theory and Practice 2017;23(3):292-297
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression changes of astrocytic syntrophin in hippocampus from human mesial temporal lobe epilepsy (MTLE). Methods From April, 2015 to July, 2016, 17 cases of hippocampus, collected from temporal lobectomy, were divided into MTLE group (n=13) and non-MTLE group (n=4) according to hematoxylin and eosin staining, glial fibrillary acidic protein and neuronal nu-clei immunohistochemical staining. Immunofluorescence double labeling and immunofluorescence histochemistry were used to observe the expression of syntrophin. Results The proliferation of astrocytes increased and neurons reduced in the hippocampus of MTLE group. Syntro-phin was found in the membrane and foot processes of astrocyte, that was enriched along perivascular astrocyte end-feet domain in non-MTLE group, but lost in MTLE group. While the whole expression of syntrophin was more in MTLE group than in non-MTLE group (t=5.421, P<0.001). Conclusion The distribution of syntrophin in hippocampus astrocytes may be related to the development of MTLE.