The Efficacy of Amniotic Membrane Graft in the Treatment of Symptomatic Bullous Keratopathy.
10.3341/jkos.2007.48.8.1036-1040
- Author:
Jung Hyun PARK
1
;
Jin Wook JEOUNG
;
Won Ryang WEE
;
Jin Hak LEE
;
Mee Kum KIM
;
Jae Lim LEE
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. kmk9@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Amniotic membrane transplantation;
Bullous keratophathy;
Epithelization;
Preservation
- MeSH:
Amnion*;
Epithelium;
Follow-Up Studies;
Humans;
Pain, Intractable;
Retrospective Studies;
Transplants*
- From:Journal of the Korean Ophthalmological Society
2007;48(8):1036-1040
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the efficacy of amniotic membrane (AM) transplantation in symptomatic bullous keratopathy using cryo-preserved or lyophilized AM. METHODS: Eight bullous keratopathic patients, who experienced intractable pain despite medication and the application of a therapeutic lens, underwent permanent AM transplantation with 5 cryo-preserved and 3 lyophilized AMs following removal of epithelium using a trephine. The time to re-epithelization and the subsidence of pain were evaluated retrospectively. RESULTS: Mean follow-up was 252+/-171.0 days. Pain relief and re-epithelization were obtained in all eight patients. The times to complete relief of pain was 32.2+/-22.7 days in patients with cryo-preserved AM transplantations (n=5) and 22.0+/-18.0 days in those with lyophilized AM transplantations (n=3) (p=0.549, Mann-Whitney U test). Respective times to re-epithelization were 25.4+/-20.7 days and 23.0+/-25.2 days (p=0.297). There were no significant differences in the diameter of transplanted AMs between the two groups (7.6+/-0.2 vs. 7.3+/-0.3 mm, p=0.172). CONCLUSIONS: Permanent AM transplantation effectively reduced the intractable pain caused by epithelial bulla. Whether the AM was cryo-preserved or lyophilized did not affect the efficacy of the treatment.
