Correlation between BRAF gene mutation and papillary thyroid carcinoma

VernacularTitle:BRAF基因突变与甲状腺乳头状癌的相关性
Author: Mingyu HAO
Keywords: Papillary thyroid neoplasms; BRAF gene; Gene mutation; MAPK signaling pathways
From: Cancer Research and Clinic 2017;29(3):211-213
CountryChina
Language:Chinese
Abstract: Papillary thyroid carcinoma (PTC) is a common tumor in endocrine system with unclear pathogenesis. The study has shown that the stimulation of cell growth, differentiation and gene mutation factors act together on the thyroid gland cells to transform into tumor cells from normal cells. A variety of oncogenes and tumor suppressor genes are involved in the development of PTC. In recent years, the study has found that BRAF gene mutation has a close relationship with the pathogenesis and prognosis of PTC. Mutated BRAF gene affects the occurrence and development of PTC owing to the regulation by RAS protein kinase and the application of biological function by activating MAPK signaling pathways.