Phage display technology and tumor targeted therapy
10.3760/cma.j.issn.1006-9801.2017.03.019
- VernacularTitle:噬菌体展示技术与肿瘤靶向治疗
- Author:
Lidan HOU
- Keywords:
Phage display;
Random peptide library;
Neoplasms;
Molecular targeted therapy
- From:
Cancer Research and Clinic
2017;29(3):214-216
- CountryChina
- Language:Chinese
-
Abstract:
Phage display technology is a kind of laboratory technique by means of genetic engineering to combine phage with exogenous genes, based on the presentation of a heterogeneous peptide or protein libraries on the surface of phage along with phage coat protein expressions. The displayed proteins or peptides could maintain their own relative spatial structure and biological activity, allowing them to direct phage binding to a target of interest. Therefore, the technology can be widely used as a simple and effective screening tool to screen successfully tumor-targeted peptides, deliver tumor-targeted drugs and prepare tumor antibody, which plays an important role in tumor-targeted therapy.
