Preparation of Vitamin B1 Sustained-release Tablets
- VernacularTitle:维生素B1缓释片的制备工艺研究
- Author:
Guo LIAN
;
Hong ZHANG
;
Yuanguo XIONG
- Keywords:
Vitamin B1;
Sustained-release tablets;
Preparation process;
In vitro dissolution rate
- From:
China Pharmacist
2017;20(3):453-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To screen the optimal formula and preparation process of vitamin B1 ( VB1 ) sustained-release tablets. Methods:The single-factor tests were used to investigate the type of filler, type and amount of matrix material hydroxypropyl methycel-lulose(HPMC), type and amount of retarder, tablet weight and core hardness. The orthogonal tests were used to investigate the amount of HPMC and ethyl cellulose( EC) and the core hardness. Results:The optimum formula was as follows:HPMC accounted for 50% of the tablet weight, EC accounted for 20%, the filler was lactose, the tablet weight was 200 mg and the tablet core hardness was 50 N. Conclusion:The prepared sustained-release tablets have significant controlled-release property, which provides reference for the devel-opment of new dosage form for VB1 .
