Development Toxicity of Ningmitai Capsules on Embryo and Fetus of Mice
- VernacularTitle:宁泌泰胶囊对小鼠胚胎和胎仔发育毒性研究
- Author:
Bangxuan ZHU
- Keywords:
Ningmitai capsules;
Mouse;
Embryo and fetal toxicity;
Teratogenicity
- From:
China Pharmacist
2017;20(3):571-573
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the matrix toxicity, embryo-fetal development toxicity and teratogenicity of Ningmitai capsules with oral administration in pregnant mice. Methods:After successful mating, the female mice were given Ningmitai capsules respec-tively at the dose of 5. 2, 10. 4 and 20. 7 g·kg-1 ·d-1 from the 6th to 15th day with gavage administration, and those in the control group were given saline. The body weight was recorded during the whole study. On the 18th day, the pregnant mice were dissected, and the number of corpora lutea, live fetus, dead fetus and absorptive fetus was recorded, respectively, and the appearance, body weight, skeleton and internal organs were observed. Results:No notable abnormality showed in the above indices in the pregnant mice and the embryo and fetus, and there were no statistically significant differences between Ningmitai capsules group and the control group. Con-clusion:Under the experimental conditions, Ningmitai capsules show no obvious toxicity on matrix, embryo and fetus of mice.
