Risk factors for cognitive impairment in obstructive sleep apnea-hypopnea syndrome patients with ischemic stroke
10.3969/j.issn.1009-0126.2017.02.015
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征合并脑梗死患者认知功能障碍相关危险因素的研究
- Author:
Xin ZHANG
;
Yaning ZHAO
- Keywords:
sleep apnea syndromes;
brain infarction;
cognition disorders;
risk factors
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2017;19(2):167-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors for cognitive impaurment in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with ischemic stroke.Methods Three hundred and twenty-eight OSAHS patients with ischemic stroke were divided into cognitive impairment group (n=158) and cognitive impairment-free group (n=170) according to their MMSE score.The risk factors for their cognitive impairment were analyzed by multivariate logistic regression analysis and stratification analysis respectively.Results The blood glucose and lipid,AHI,LSaO2,infarction size and site,HIF-1 and Ngb level were significantly different between the two groups (P＜0.01).Multivariate logistic regression analysis showed that blood glucose and lipid,AHI,infarction site and Ngb level were the independent risk factors for cognitive impairment (OR=3.527,95％CI:1.559-7.983,P=0.002;OR=6.413,95 ％CI:2.766-14.865,P=0.000;OR=4.099,95％CI:1.694-9.918,P=0.002;OR=4.484,95％CI:1.950-10.310,P=0.000;OR=3.891,95 ％CI:1.759-8.606,P=0.001).Stratification analysis showed that high HIF-1 and Ngb levels were positively related with cognitive impairment in patients with AHI＞20 times/h,frontotemporal infarction,hyperglycosemia or hypoglycosemia,and dyslipidemia.Conclusion High HIF-1 and Ngb levels are independently related with cognitive impairment in OSAHS patients with ischemic stroke.
