Clinical study of human papillomavirus 16 integrated role in the pathogenesis of cervical cancer

VernacularTitle:人乳头瘤病毒16的整合作用在不同宫颈病变组织中的表达及意义
Author: Xiaojuan SUN ; Jian WANG
Keywords: Human papillomavirus; Cervical cancer; Integration
From: Clinical Medicine of China 2017;33(1):18-21
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of the integration of human papillomavirus 16 on the cervical cancer patients.Methods Outpatient colposcopy cervical liquid-based cytology examined (TCT)information in Kailuan General Hospital and Linxi Hospital of Kailuan General Hospital from January 2014 to June 2015 were selected.The Results of TCT were positive in 180 patients with as case group,were negative in 128 patients as control group.The effect of the integration of human papillomavirus 16 was analyzed.Results In the case group,there were 86 cases with HPV-positive,37 cases with HPV16-positive,10 cases with HPV16-free,10 cases with HPV16-concomitant,17 cases with HPV16-integration,and the integrated rate was 46.0％.While in the control group,there were 20 cases with HPV-positive,3 cases with HPV16-positive and all of them were HPV16-free.The integration degree was significantly higher than the control group (P =0.000).Conclusion The integration of human papillomavirusl6 has much significant influence on the cervical cancer.