Introduction to connection between chemotherapy tolerance, metastasis and micro-environment in breast cancer
10.3760/cma.j.issn.1008-1372.2017.02.001
- VernacularTitle:浅谈乳腺癌化疗耐药、转移与微环境
- Author:
Zhimin HE
;
Guopei ZHENG
- Keywords:
Breast neoplasms;
Drug therapy;
Drug tolerance;
Neoplasm invasiveness;
Neoplasm metastasis;
Editorial
- From:
Journal of Chinese Physician
2017;19(2):161-162
- CountryChina
- Language:Chinese
-
Abstract:
This review article briefly described the interaction and inner link between chemotherapy tolerance and metastasis of breast cancer.The common pathways of occurrence of drug resistance and metastasis were analyzed with formation and outcome of breast cancer epithelial-mesenchymal transition (EMT) and with enrichment and function of breast cancer stem cells.The chemotherapy which play positive role in clinical practice was pointed out that may cause negative effects by changing tumor microenvironment.Those evidences show that the theory on tumor microenvironment will help to formulate the research strategies for preventing and reversing resistance of breast cancer to drug and metastasis.
