A review on the application of animal models in preclinical research of the treatment of liver diseases with mesenchymal stem cells
10.3969/j.issn.1005-4847.2017.01.019
- VernacularTitle:动物模型在间充质干细胞治疗慢性肝病临床前研究的应用
- Author:
Xufeng FU
;
Bingbing CHEN
;
Yaping YAN
;
Hong WANG
;
Junfeng WANG
;
Bingrong ZHENG
;
Wei SI
- Keywords:
Liver disease;
animal models;
Mesenchymal stem cells;
MSCs;
Preclincal study
- From:
Acta Laboratorium Animalis Scientia Sinica
2017;25(1):102-106
- CountryChina
- Language:Chinese
-
Abstract:
Chronic liver diseases can further develop to liver fibrosis and cirrhosis. Currently, there is no effective treatment except liver orthotopic transplantation at this point. The extreme shortage of liver organ source forced people to find alternative treatment strategies. Mesenchymal stem cells ( MSCs) have the abilities of immunomodulatory, hepatocyte differentiation, promotion of liver cells regeneration in situ and inhibiting the activation of hepatic stellate cells. Therefore, MSCs transplantation provides a very broad prospect for cell therapy. It is important to provide preclinical evaluation of the efficacy and safety before the application of cell therapy in clinical trials. The progress of various animal models of human liver diseasees and significance of using MSCs to treat liver diseases in preclincal studies based on these animal models were reviewed in this paper.
