The comparison of prescription pattern, adverse events, economic burden and drug-use adherence be-tween the different preferred drug in bipolar disorder
10.3969/j.issn.1002-0152.2016.12.007
- VernacularTitle:双相障碍不同首选用药间处方方式、不良反应、 经济负担、依从性比较
- Author:
Wei CUI
;
Yunshu ZHANG
;
Baoping YAN
;
Keqing LI
;
Lijun CUI
;
Yumin CHENG
;
Xin ZHANG
- Keywords:
Bipolar disorder;
Mood stabilizers Antipsychotics;
Adverse effect;
Economic burden
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(12):737-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences of prescription pattern, adverse events, economic burden and drug-use adherence between preferred mood stabilizers and preferred antipsychotics in patients with bipolar disorder. Methods We investigated 240 cases of patients with bipolar disorder from 39 mental health institutions in 11 cities in Hebei province. The self-made questionnaire was used to investigate the demographic information, disease characteris-tics, prescription pattern and medical expense. The clinical global impression scale-severity of illness (CGI-SI) was used to assess the disease severity. The treatment emergent symptom scale (TESS) was used to assess the adverse drug reac-tions. The medication adherence rating scale (MARS) was used to assess drug therapy compliance in patients. Results One hundred fifty-two patients (63.3%) used antipsychotics as the first choice (antipsychotics group), 88 patients (36.7%) used mood stabilizers as the first choice (mood stabilizers group). The number of patients in-patient (90.1%vs. 76.1%), patients with psychotic symptom (27.0%vs. 11.4%), incidences of adverse events (46.1%vs. 31.8%), drug daily cost (me-dians 12.00 yuan vs. 8.37 yuan) and drug total cost (medians 344.61 yuan vs. 144.64 yuan) were larger in antipsychotics group than in mood stabilizers group (P<0.05). There was no significant difference between two groups in pattern of pre-scription, severity of adverse events and total scores of MARS (P>0.05). Conclusion The bipolar disorder patients more frequently use antipsychotics as the first choice in Hebei province. The use of antipsychotics does not alter the combina-tion medication pattern. In addition, antipsychotics cause a higher incidence of adverse events and heavier economic bur-den compared with mood stabilizers, suggesting that mood stabilizers should be the first choice to bipolar disorder.
