Analysis of mutation of 20 autosomal short tandem repeat loci in Henan Han population

VernacularTitle:河南汉族群体20个常用STR基因座突变分析
Author: Lin ZHANG ; Kejie WANG ; Hongyan WU ; Aiying FAN ; Xupeng SUN ; Zhendong ZHU
Keywords: forensic biological evidence; short tandem repeat loci; mutation rate; paternity testing
From: Chinese Journal of Forensic Medicine 2017;32(1):33-35
CountryChina
Language:Chinese
Abstract: Objective To investigate the mutation phenomenon of 20 autosomal STR loci in Henan Han population. Methods A total of 3011 parentage confirmed cases were collected to screen mutation events, ascertain the source of mutation, calculate mutation rate, analyze mutation rules and compare with the mutation condition of populations in different regions. Results 76 mutation events were observed in 19 STR loci, the average and accumulative mutation rate reached to 0.08% and 1.6629%, respectively. The ration of paternal versus maternal mutation was 8:1. Mutation rates of Penta E and D12S391 loci in Henan Han population were lower than the Han population of northern China(P<0.05); the mutation rate of CSF1PO locus were lower than Guangdong population and Yunan Han population(P<0.05); the mutation rates of D6S1043 and D12S391 loci were lower than Guangdong population(P<0.05). Conclusion STR mutation events were common in paternity testing. Region differences among mutation rate were significant.