Postmortem Redistribution of Avermectin in Acute Poisoning death of Rabitts
10.13618/j.issn.1001-5728.2017.01.017
- VernacularTitle:阿维菌素在急性中毒死家兔体内的再分布研究
- Author:
Biao MU
;
Hongjiang YU
;
Yanxu LU
- Keywords:
forensic toxicology;
avermectin;
rabbit;
clinical death time;
postmortem redistribution
- From:
Chinese Journal of Forensic Medicine
2017;32(1):60-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the postmortem redistribution of Avermectin in acute poisoning death of rabitts. Methods According to the minimum lethal dose intragastric of 250mg/kg avermectin, the avermectin contents in the heart blood and major organs and tissues of the rabitts after death of 0h~72h were assayed by HPLC method. Results Determination of clinical death time was 120.6±9.2min(x±s, n=10)by intragastric 250mg/kg avermectin to the rabitts; Lethal blood concentrations and lethal tissue concentrations of Avermectin were determined; Presence of postmortem redistribution of avermectin contents in the heart blood and major organs and tissues of the rabitts after death of 0h~72h were proved; Determination of the liver, kidney and lung were the best tissue samples for toxicological anaysis. Conclusion The data of Avermectin postmortem redistribution in the rabbits have important reference value for the forensic management of such cases.
