Effect of Water Extract from Salvia Miltiorrhiza on the Hair Regrowth in Testosterone-induced Alopecia in Mice
- VernacularTitle:丹参水提物对小鼠病理脱发模型毛发的再生影响
- Author:
Zhibi ZHANG
;
Chao DONG
;
Jiao MA
;
Guohua FENG
- Keywords:
Water exact from salvia miltiorrhiza;
Androgeneic alopecia;
Hair regrowth;
Testosterone
- From:
Journal of Kunming Medical University
2016;37(11):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of water exact from salvia miltiorrhiza (SM) in promoting hair regrowth in testosterone (T)-induced alopecia in mice.Methods Pathological alopecia mice were induced by T and the mice were randomly divided into control group,model group,Zhanggvanp 101 group,SM low-dose group,SM middle-dose group,SM high-dose group (20,40,80 mg/ml,respectively).The effects of SM on hair regrowth were evaluated by measuring hair length,weight and the number of hair follicle.The concentration of serum T and estrodiol (E2),the content of skin VEGF,MDA,SOD,and GSH-Px were measured after external inunctum for 21 days.Results (1) SM significantly promoted regrowth hair length,weight and the number of hair follicle (P＜0.05) (2) SM significantly balanced the hormones by reducing levels of T and increasing E2 (P＜0.05) (3) SM significantly reduced the content of MDA by increasing the activity of SOD and GSH-Px (P＜0.05) (4) SM significantly increased the level of VEGF (P＜0.05) Conclusion In the pathological alopecia mice induced by T,SM can effectively promote the hair regrowth,with the possible mechanism of balancing hormones,being anti-oxidant and improving VEGF expression.
