Effect of Saponins Ⅰ Extracted from Paris Polyphylla on Coronary Artery Endothelial Cell Proliferation
- VernacularTitle:重楼皂苷Ⅰ对体外抑制冠状动脉内皮细胞增殖的影响
- Author:
Weiwei WANG
;
Xuesong WU
;
Hongmiao ZHANG
;
Wen ZHANG
;
Ying ZHANG
;
Hong YE
;
Tianhao BAO
- Keywords:
ParidissaponinⅠ;
Coronary heart disease;
Coronary artery endothelial cell;
Cadherin;
Proliferation
- From:
Journal of Kunming Medical University
2016;37(11):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of ParidissaponinⅠ (PSⅠ) on the proliferation of coronary artery endothelial cells (CAECs).Methods CAECs were cultured with PSⅠ.CAEC growth rate was calculated by using blood cell counting plate.Cell viability was measured by MTT.The expressions of cadherin and caspase3 mRNA were detected by RT-PCR.Results PSⅠ slowed down growth rate of CAECs,reduced cell viability of CAECs,decreased the expression of cadherin mRNA and increased the expression of caspase3 mRNA in CAECs.Conclusion PSⅠ inhibits the proliferation of CAECs and induces CAECs apoptosis.
