Application of Serum VEGF-C, VEGFR-2 and VEGFR-3 Expression Level in Monitoring Curative Effects and Prognosis of Acute Leukemia
- VernacularTitle:血清VEGF-C、VEGFR-2、3表达水平在急性白血病疗效监测及预后判断中的应用
- Author:
Xiufen SHEN
;
Li XUE
;
Shourui FAN
;
Xiaojuan HE
;
Xuejiao WANG
;
Jingxing YU
;
Meihua XIA
;
Liefen YIN
- Keywords:
Acute leukemia;
Vascular endothelial growth factor;
Vascular endothelial growth factor receptor;
Enzyme-linked immuno sorbent assay
- From:
Journal of Kunming Medical University
2016;37(11):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe expression level of serum vascular endothelial growth factor-C (VEGF-C),VEGF-C receptor-2 and VEGF-C receptor-3 in patients with acute leukemia (AL) and to explore its clinical significance.Methods Enzyme-linked immuno sorbent assay (ELISA) was used to detect the serum expression levels of VEGF-C,VEGFR-2,and VEGFR-3 of 51 patients diagnosed with acute leukemia,43 patients under medical treatment and 16 healthy blood donors.Results (1) Serum VEGF-C,VEGFR-2,and VEGFR-3 expression levels in AL patients were significantly higher than those in normal control group.(2) Serum VEGF-C and VEGFR-2 expression levels in complete remission (CR) group significantly declined after treatment.Serum VEGF-C and VEGFR-2 expression levels in non-complete remission (NR) group slightly declined after treatment but no significant difference was found (P＞0.05).(3) No significant difference was found in serum VEGFR-3 expression levels both in CR group and NR group after treatment (P＞0.05).(4) Serum VEGF-C,VEGFR-2,and VEGFR-3 expression levels in NR group were significantly higher than those in CR group before treatment (P＜0.08).Conclusions Observing serum expression level of VEGF-C,VEGFR-2,and VEGFR-3 of AL patients may be helpful in monitoring curative effects and prognosis of acute leukemia.
