Effects of the Mongolian Medicine Carthamus Tinctorius on TNF-α Expression and Hepatocyte Apoptosis in Rats with Acute Liver Injury

VernacularTitle:蒙药红花对急性肝损伤大鼠TNF-α表达及肝细胞凋亡的影响
Author: Xin LIU ; Meirong BAI
Keywords: Mongolian medicine Carthamus tinctorius; acute liver injury; TNF-α; apoptosis
From: Journal of China Medical University 2017;46(2):116-119
CountryChina
Language:Chinese
Abstract: Objective To observe the protective effect of Mongolian medicine Carthamus tinctorius in acute liver injury induced by D-GlaN(D-galactosamine)in rat models. Methods The acute liver injury model was established by intragastric administration D-GlaN in rats. The levels of serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutathione(GSH-Px),the content of tumor necrosis factor-α(TNF-α)in liver tissue and the apoptosis of hepatocytes were determined. Results Mongolian medicine safflower can significantly reduce the activity of serum ALT and AST and liver tissue GSH-Px,and the degree of cell apoptosis;however,no obvious change of the TNF-αcontent was observed. Conclusion The Mongolian medicine Carthamus tinctorius has protective effect in D-GlaN-induced acute liver injury rats probably via anti-oxi-dative and anti-apoptotic abilities.