Expressions of GLP-1R and CK17 in papillary thyroid cancer and clinical significance
10.3969/j.issn.1671-8348.2017.07.017
- VernacularTitle:GLP-1R和CK17在甲状腺乳头状癌中的表达及临床意义
- Author:
Xi ZENG
;
Jia CHEN
;
Yi TIAN
- Keywords:
thyroid neoplasms;
glucagon-like peptide-1 receptors;
cytokeratin 17;
immunohistochemistry;
immunoblotting
- From:
Chongqing Medicine
2017;46(7):919-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of glucagon-like peptide-1 receptors (GLP-1R) and cytokeratin17 (CK17) in papillary thyroid cancer tissue and clinicopathological significance.Methods The immunohistochemistry and immunoblotting method were employed to detect the expressions of GLP-1R and CK17 in normal thyroid tissues (control group,50 cases) and papillary thyroid cancer tissue (observation group,80 cases).Then the correlation between the expressions of GLP-1R and CK17 with pathological factors of thyroid cancer was analyzed.Results Low expression of GLP-1R was found in 22 cases (44.00 ％) of the control group,while GLP-1R was expressed in 77 cases(96.25 ％) of the observation group,and the difference between both groups was statistically significant(P＜0.01).The expression of CK17 was positive in 8 cases(16.00％) of the control group,while 77 cases(96.25 ％) in the observation group were CK17 expression positive,and the difference between both groups was statistically significant(P＜0.01).The difference between GLP-1 positive expression and clinicopathologic factors had no statistical significance(P＞0.05).The difference between CK17 expression with sex and age had no statistical significance (P＞0.05),and was obviously related with the tumor diameter,clinical stages and cervical node metastasis of thyroid neoplasms(P＜0.05).Conclusion GLP-1R and CK17 all are highly expressed in papillary thyroid cancer tissue and CK17 expression is obviously related with the tumor diameter,clinical stages and cervical node metastasis of papillary thyroid cancer.
