Effect of denatonium benzoate on airway inflammation and remodeling in asthmatic mice
10.3969/j.issn.1671-8348.2017.06.010
- VernacularTitle:苦味受体激动剂苦精对哮喘气道炎症及重塑的影响
- Author:
Shan YAN
;
Li CHENG
;
Xiaoning ZHAO
;
Yimin HUANG
;
Li LIU
;
Jingjing LIU
;
Fusheng GAO
- Keywords:
bitter taste receptor;
denatonium benzoate;
asthma;
airway inflammation;
airway remodeling
- From:
Chongqing Medicine
2017;46(6):752-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of denatonium benzoaten on α-smooth muscle actin (α-SMA),subepithelial collagen and airway inflammation in asthmu mice.Methods Forty-five BALB/c mice were divided into 3 groups,normal control group (A group),asthma model group (B group),asthma model+ denatonium benzoaten group(C group);α-SMA detected by using immunohistochemistry,lung sections were stained with Masson to detect subepithelial collagen,HE stain method was used to observe the airway inflammation the images were analyzed with semi-quantitative computer.Results The deposition of α-SMA、subepithelial collagen and inflammation degree in C group was significantly reduced compared with B group,the difference were statistically significant(P＜0.05).Conclusion Denatonium benzoaten can improve airway remodeling in asthmatic mice.
