The expression and significance of YB-1 in cervical squamous carcinoma
10.3969/j.issn.1671-8348.2017.06.018
- VernacularTitle:YB-1蛋白在宫颈鳞状细胞癌组织中的表达及临床意义
- Author:
Xue LIAO
;
Qianchuan REN
- Keywords:
Y-box binding protein-l;
neoplasms,squamous cell;
uterine cervical neoplasms;
prognosis
- From:
Chongqing Medicine
2017;46(6):777-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of YB-1 and to research the relationship in the occurrence and development in the cervical squamous carcinoma(SCC) tissues.Methods Immunohistochemistry(IHC) envision was used to detect the expression of chronic cervicitis,CIN Ⅰ,CIN Ⅱ-Ⅲ and SCC.The relationship of YB-1 in the clinical pathological parameters of SCC were analyzed.Results YB-1 was mainly located in the nucleus in squamous cell,sometimes in the cytoplasm.The YB-1 protein did not expression in chronic cervicitis.In CIN Ⅰ,CIN Ⅱ-lⅢ and SCC,the positive expression had a gradual increasing trend.The expression of YB-1 was satistically significant in four groups (P＜0.05).The chronic cervicitis group,CIN Ⅰ groupCIN Ⅱ-Ⅲ group compared with the SCC group restivelly,the difference was statistically significant (P＜0.05).From spearman rank correlation analysis:the expression of YB-1 was positively correlated with the degree of cervical lesions (P＜ 0.05).In the cervical squamous carcinoma group,the expression of YB-1 was not associated with clinical pathological index of SCC patients(P＞0.05).Conclusion The change of the quantity of YB-1 protein is closely related to cervical squamous cell carcinoma.
