The relationship between MMP-1 genetic polymorphisms and dental implant early failure in Chinese Han nationality

VernacularTitle:基质金属蛋白酶-1基因多态性对汉族人群牙种植早期失败的影响
Author: Shilin HE ; Peng XU ; Shi BAI
Keywords: dental implants; matrix metalloproteinase 1; genetic research; polymorphism
From: Chongqing Medicine 2017;46(5):635-637
CountryChina
Language:Chinese
Abstract: Objective To make clear the relationship between the genetic polymorphism of MMP-1 and implant early failure.Methods We conducted a case control study,53 cases patients (no smoking history and without periodontitis) who have underwent dental implant were divided into experimental group(with dental implant failure) and control group(with dental implant success) according to early failure of dental implant (within one month).DNA of 53 patients in Han nationality were extracted by using Chelex-100 method and polymorphisms of the mmp-1-1607 gene were detected by restriction fragment length polymorphism after polymerase chain reactions.Results Patients with MMP-1-1607(1G/2G) genotype exhibited a significantly higher occurrence of implant early failure than those with MMP-1-1607(1G/1G) gene type(P＜0.05).The OR of the 1G/2G versus the 1G/1G of the MMP-1-1607 genotype was 13.894(P＜0.05).Conclusion MMP-1-1607(1G/2G) genotype is associated with implant early failure.