Diagnosis and treatment of special T-lymphoblast lymphoma: report of one case and review of literature

VernacularTitle:特殊T淋巴母细胞淋巴瘤一例诊治并文献复习
Author: Tingyu WANG ; Zengjun LI ; Rui LYU ; Shiqiang QU ; Shuhui DENG ; Wei LIU ; Lugui QIU
Keywords: Lymphoblast lymphoma; Myeloid and lymophoid neoplasms; Imatinib; Eosinophilia
From: Journal of Leukemia & Lymphoma 2017;26(3):177-180
CountryChina
Language:Chinese
Abstract: Objective To investigate the correct diagnosis and treatment of myeloid and lymophoid neoplasms with eosinophilia and the FIP1L1-PDGFR fusion gene. Methods A case of patient who was diagnosed as myeloid and lymophoid neoplasms with eosinophilia and the FIP1L1-PDGFR fusion gene was reported, and the literature was reviewed. Results The patient was diagnosed as typical T-lymphoblast lymphoma (T-LBL) by the lymph node pathologic diagnosis, while the diagnosis of myeloid and lymophoid neoplasms with eosinophilia and the FIP1L1-PDGFR fusion gene was made correctly by the whole examination and analysis. The patient acquired deep complete remission quickly after taking the low dose of imatinib. Conclusions Myeloid and lymophoid neoplasms with eosinophilia and the FIP1L1-PDGFR fusion gene are a rare hematologic tumor. Though pathological diagnosis is the golden standard for lymphoma, sometimes the other factors should be taken into consideration and make an overall analysis of clinical picture and a correct view of the pathological diagnosis, which could avoid the misdiagnosis and improper treatment.