Clinical efficacy of emedastine difumarate combined with pranoprofen eye drops in allergic conjunctivitis and its influence on related indicators
10.3969/j.issn.1005-1678.2017.03.067
- VernacularTitle:富马酸依美斯汀联合普拉洛芬滴眼液治疗过敏性结膜炎的临床疗效及对患者相关指标的影响
- Author:
Liangliang SUN
;
Zheng ZHANG
;
Aihua WU
- Keywords:
emedastine difumarate eye drops;
pranoprofen eye drops;
allergic conjunctivitis;
histamine;
eosinophil cationic protein;
leukotrienes B4;
IgE
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):219-221
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of emedastine difumarate eye drops combined with pranoprofen eye drops on histamine (HA), eosinophil cationic protein (ECP), leukotrienes B4(LTB4) and, IgE levels of allergic conjunctival and provide reference for clinical diagnosis and treatment.Methods 76 cases of patients with allergic conjunctivitis were randomly divided into control group and experimental group , control group were treated with fumaric acid emedastine eye drops, experimental group were treated with fumarate emedastine combined with pranoprofen eye drops, and then compare the efficacy and serum ECP, HA, LTB4 and IgE levels between two groups before and after treatment of the symptoms and signs score . Results The total efficacy of experimental group was significantly higher than that in control group (94.70%vs.81.60%)(P<0.05).The serum ECP, HA, LTB4 and IgE levels of experimental group were significantly lower than those in control group(P<0.05).Conclusion The emedastine difumarate combined with pranoprofen eye drops in the treatment of allergic conjunctivitis is better than single medication, and ECP, HA, LTB4, IgE significantly decrease.
