Carbetocin combined with oxytocin for prevention of bleeding after artificial abortion
10.3969/j.issn.1005-1678.2017.03.072
- VernacularTitle:卡贝缩宫素与缩宫素联用预防药物流产后出血的临床研究
- Author:
Rong LU
;
Xuyue JIA
;
Yinjie CHEN
- Keywords:
caebetocin;
oxytocin;
artificial abortion;
postoperative bleeding
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):234-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the carbetocin combined with oxytocin for prevention of bleeding after artificial abortion .Methods 110 cases of pregnant women undergoing artificial abortion were randomly divided into observation group and control group.Observation group were treated with carbetocin combined with oxytocin treatment, the control group were treated by oxytocin treatment, the negative blood loss, menstrual recovery changes and curative effect in two groups of patients were compared.Results The total efficiency of the observation group was 96.36%, was significantly higher than the control group 78.18%, the difference was statistically significant (P<0.05), the 24h negative bleeding volume, vaginal bleeding time, menstruation time, first menstrual duration in the observation group were lower than those in control group, the difference was statistically significant (P<0.05).The vaginal bleeding time less than 7d in observation group of patients accounted for 30.91%, was significantly higher than the control group 18.18%; the time of vaginal bleeding >14d accounted for 3.64%, significantly lower than the control group 21.82%, the difference was statistically significant (P<0.05).The vaginal bloodmenstrual volume accounted for more than 9.09%, was lower than 32.73%in the control group, the difference was statistically significant (P<0.05).The sex hormone in two groups of patients before and after the treatment had no significant difference.The progesterone level in observation group was lower than the control group, estradiol level was higher than the control group, the difference was statistically significant (P<0.05), the adverse reaction rate in control group was 12.73% compared with 7.27% in the observation group, the difference was no statistically significant.Conclusion The abortion patients after treated with carbetocin combined with oxytocin treatment can reduce the amount of vaginal bleeding, shorten the bleeding time and menstrual recovery time, safe and reliable curative effect.
