Effects of exectin hydrochloride combined with intensity modulated radiotherapy on CEA, NSE and CA199 levels in advanced lung cancer
10.3969/j.issn.1005-1678.2017.03.088
- VernacularTitle:盐酸埃克替尼联合调强放疗对晚期肺癌患者CEA、NSE、CA199水平的影响
- Author:
Xiaohui JIN
;
Ming ZHANG
;
Qing XU
- Keywords:
exectin hydrochloride;
intensity modulated radiotherapy;
lung cancer;
carcinoembryonic antigen;
neuron-specific enolase;
serum glycoprotein antigen 199
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):282-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effects of exectin hydrochloride and intensity modulated radiotherapy in treatment of patients with advanced lung cancer and its effect on levels of carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and serum glycoprotein antigen 199 (CA199). Methods 88 patients with advanced lung cancer were selected from June 2014 to June 2016 in our hospital were selected and randomly divided into observation group and control group, 44 cases in each group.In the control group, the patients were treated with IMRT, and the observation group was treated with exectin hydrochloride on the basis of control group.The clinical efficacy and adverse reaction were compared between the two groups.The levels of CEA, NSE and CA199 before and after treatment were analyzed.Results After treatment, the total effective rate in the observation group 84.09% was significantly higher than the control group 52.27%, the difference was statistically significant (P<0.05).Before treatment, the levels of CEA, NSE and CA199 of the two groups had no significantly different, after treatment, the levels of CEA, NSE and CA199 of the two groups were significantly lower than before treatment, the difference was statistically significant (P<0.05).CEA, NSE, CA199 levels in the observation group were significantly lower than the control group, the difference was statistically significant (P<0.05).There was no significant difference in adverse reaction rate of I-II, III-IV liver function, gastrointestinal reaction, bone marrow suppression and acute radiation pneumonitis in observation group and control group.Conclusion Ectectin hydrochloride combined with intensity modulated radiotherapy can effectively reduce the levels of CEA, NSE and CA199 in patients with advanced lung cancer, and the clinical efficacy is good, and will not increase the adverse reaction rate.
