Changes of serum inflammatory mediators in secondary septic shock after chemotherapy for acute leukemia
10.3969/j.issn.1005-1678.2017.03.090
- VernacularTitle:急性白血病化疗后继发感染性休克患者血清炎性介质变化研究
- Author:
Feiyan YU
;
Zhenhua WANG
;
Xiaolin GU
- Keywords:
acute leukemia;
secondary septic shock after chemotherapy;
serum inflammatory mediators
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):288-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and analyze the change state of serum inflammatory mediators of patients with secondary septic shock after chemotherapy for acute leukemia .Methods 56 patients with secondary septic shock after chemotherapy for acute leukemiawere were selected as the group A,56 patients without secondary septic shock after chemotherapy for acute leukemia were selected as the group B ,56 healthy persons of the same age were selected as the group C,then the serum inflammatory mediators levels of three groups were detected and compared,and the serum indexes of group A with different severity degree of shock were compared, then the detection results of group A and group B with different types ( lymphocytic leukemia and nonlymphocytic leukemia)were compared.Results The serum inflammatory mediators levels, including TNF-α, IL-4, IL-6, IL-10 and other inflammatory factors, including PGE2 , sICAM-1, sVCAM-1 and sCD44, there were group A >group B >group C, severe shock >moderate shock>mild shock ( all P<0.05 ) .The above serum inflammatory mediators and other inflammatory factors levels of different types in group A were higher than those in group B, and the above mediators in lymphocytic leukemia of group A and group B were higher than those in nonlymphocytic leukemia (all P<0.05).Conclusion The serum inflammatory mediators of patients with secondary septic shock after chemotherapy for acute leukemia show higher expression state,and the influence of shock degree and leukemia types for the expression are great.
