Clinical analysis of different routes of administration of methotrexate combined with hysteroscopy in cesarean scar pregnancy
10.3969/j.issn.1005-1678.2017.03.096
- VernacularTitle:甲氨蝶呤不同给药途径联合宫腔镜手术治疗剖宫产瘢痕妊娠的临床分析
- Author:
Xuedong TANG
;
Shengfeng XU
;
Li LING
- Keywords:
cesarean scar pregnancy;
methotrexate;
hysteroscopy
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):307-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of methotrexate incision and different methods of administration combined with hysteroscopic surgery for cesarean scarpregnancy (CSP).Methods Retrospective analysis of 106 patients with CSP in our hospital from January 2001 to December 2015 were.The patients were divided into two groups, group A of 66 cases: methotrexate ( MTX) incision and systemic administration combined with hysteroscopic surgery group B of 40 cases: methotrexate combined with hysteroscopy surgery.The operation time, intraoperative blood loss, preoperative hospital stay, the time of blood HCG decreased to normal, the total amount of MTX and the abnormal rate of liver function were compared between the two groups, and the factors affecting the prognosis of CSP were analyzed.Results The preoperative hospitalization time and abnormal liver function of the two groups were compared, the difference was statistically significant(P<0.05).A group of patients with success and failure, blood HCG before treatment, gestational sac and bladder wall thickness of the myometrium (MT), the difference was statistically significant (P<0.05).The median gestational sac diameter ( GS) of patients with successful treatment was 17.1 mm, and the median number of patients was 6.2 mm, and the difference was statistically significant between the two groups ( GS ) , the difference of GS between the two groups was statistically significant ( P<0.05 ) . Conclusion Methotrexate incision and systemic administration methods combined with hysteroscopy treatment compared with systemic administration combined with hysteroscopy is a safe and effective method and the hospitalization time is short, but the MT >3 mm, before treatment, blood HCG≤20000IU/L, GS≤40 mm CSP more secure.
