Expression and clinical significance of TGF-β1,Smad-3 and Smad-7 in the serum of colorectal cancer patients
10.19405/j.cnki.issn1000-1492.2017.02.031
- VernacularTitle:结直肠癌患者血清TGF-β1、Smad-3和Smad-7的表达及意义
- Author:
Xiaoxiang ZHENG
;
Wenyong WU
;
Changjun YU
- Keywords:
colorectal cancer;
TGF-β1;
Smad;
ELISA
- From:
Acta Universitatis Medicinalis Anhui
2017;52(2):285-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide clinical evidence for the relationship between epithelial-mesenchymal transition (EMT) and colorectal cancer(CRC) by detecting the expression of TGF-β, Smad-3 and Smad-7 in serum from CRC patients. Methods We detected the expression levels of TGF-β1 , Smad-3 and Smad-7 by ELISA method. Results The expression levels of TGF-β1 , Smad-3 were significantly higher and the Smad-7 was significantly lower in CRC patients than those in control group(P<0. 01). The expression levels of TGF-β1 and Smad-3 were signifi-cantly higher in Dukes D than those in Dukes B,C. The Smad-7 was significantly lower in Dukes D than that in Dukes B,C(P<0. 01). Conclusion TGF-β1 and Smad-3 and Smad-7 may play an important role in the develop-ment of CRC.
