Effect of Bairui granule and deacetylated ligustrazin injection on plasma BNP and FABP levels in children with heart failure and pneumonia
10.3969/j.issn.1005-1678.2017.03.029
- VernacularTitle:百蕊颗粒联合去乙酰毛花苷注射液对心衰合并肺炎患儿血浆BNP及FABP水平的影响
- Author:
Dandan LANG
;
Junhui YUAN
;
Junfen ZHOU
;
Sujuan GUO
;
Hongdan GU
;
Feihong CHEN
- Keywords:
Bairui granule;
deacetylated ligustrazin injection;
heart failure;
pneumonia;
BNP;
FABP
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):101-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Bairui granule and Deacetylated Ligustrazin injection on plasma BNP and FABP levels in children with heart failure and pneumonia.Methods 60 children of heart failure and pneumonia who received therapy from July 2014 to June 2016 in our hospital were randomly divided into two groups, the observation group and the control group, 30 cases in each group.children in the observation group were treated with sodium phosphate creatine, and the control group was treated with 2-linolenic acid,the clinical outcomes, clinical signs, BNF, FABP, LVEF and LVEDP were compared between the two groups.Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P<0.05); The heart rate, respiratory rate and blood oxygen saturation of the two groups were significantly improved compared with those before treatment ( P<0.05 ) , the heart rate and respiratory rate of the observation group were lower than those of the control group, the oxygen saturation was higher than that of the control group (P<0.05).After treatment, the BNF and FABP indexes of the two groups were lower (P<0.05), and the BNF and FABP indexes in the observation group were lower than those in the control group (P<0.05); The LVEF of the observation group was higher than that of the control group, the LVEDP index was lower than that of the control group, the difference was statistically significant (P<0.05).Conclusion Bairui granule and Deacetylated Ligustrazin injection in the treatment of heart failure with pneumonia has a good effect in the process, which will help reduce the BNP index in children, recovery of children's body function.
