Effect of Ganoderma capsule on expressions of CD105 protein and miR-21 in cervical cancer tumor tissue associated with HPV infection
10.3969/j.issn.1005-1678.2017.03.039
- VernacularTitle:灵芝胶囊对伴HPV感染宫颈癌患者肿瘤组织CD105蛋白及miR-21表达的影响
- Author:
Fengfeng YAN
- Keywords:
cervical cancer;
HPV infection;
Ganoderma capsule;
CD105 protein;
miR-21
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):131-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Ganoderma capsule on the expression of CD105 protein and miR-21 in cervical cancer tumor tissue associated with human papillomavirus ( HPV) infection.Methods 162 patients with HPV positive cervical cancer from the department of oncology in Cixi City Hospital of traditional Chinese Medicine were selected and divided into two groups, 81 cases in the control group were treated with neoadjuvant chemotherapy, 81 cases in the experiment group received Ganoderma capsule on the basis of the control group , the expression levels of CD105 protein, vascular endothelial growth factor (VEGF), miR-21 in tumor tissues, microvessel formation correlation indexes, peripheral blood T lymphocyte levels, and the clinical effect were compared after the treatment.Results The control rate in the control group(72.84%)was lower than the experiment group(86.41%) (P<0.05).Compared with the control group, the expression levels of CD105 protein, VEGF in tumor tissue were lower in the experiment group after treatment, serum levels of CD105 protein,transforming growth factor-β1 (TGF-β1), VEGF were lower after chemotherapy, the expression level of miR-21 was lower after treatment, peripheral blood CD4 +T lymphocytes and CD4 +/CD8 +ratio levels were higher, and the level of CD8 +T lymphocytes was lower after chemotherapy(P<0.05).Conclusion The Ganoderma capsule can significantly down regulate the expression of CD105 protein, VEGF and miR-21 in cervical cancer tumor tissue associated with HPV infection, inhibit the formation of micro blood vessels in tumor tissue, protect the immune function of patients, and improve the clinical curative effect.
