Effect of calcium dobesilate capsules in the treatment of diabetic retinopathy
10.3969/j.issn.1005-1678.2017.03.069
- VernacularTitle:羟苯磺酸钙胶囊辅助治疗糖尿病视网膜病变患者的效果观察
- Author:
Chunyuan CAI
;
Huiyun WANG
;
Zhili CHEN
- Keywords:
calcium dobesilate capsules;
diabetic retinopathy;
curative effect;
hemorheology;
vascular endothelial function;
thrombin
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):225-227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Calcium Dobesilate Capsules in the treatment of diabetic retinopathy ( DR ) and its effect on hemorheology, vascular endothelial function and thrombin.Methods According to the random number table the 80 cases of DR patients admitted in our hospital from September 2014 to August 2016 were divided into observation group and control group, 40 cases in each group, two groups of patients were treated with conventional therapy, the observation group was treated with Calcium Dobesilate capsules.Two groups of treatment were three months.Compared of the therapeutic effects, the before and after treatment changes of visual acuity, hemorheology, vascular endothelial function and thrombin index.Results The total efficiency of the observation group 92.50% was higher than the control group 72.50% (P<0.05);After treatment, two groups visual acuity increased, and the observation group after treatment higher than the control group (P<0.05); Plasma viscosity, whole blood viscosity at high shear and low shear whole blood viscosity, erythrocyte aggregation index in two groups were decreased, and observation group lower than the control group (P<0.05);Plasma NO and ET-1 levels in two groups were reduce, and observation lower than the control group after treatment (P<0.05); After treatment, two groups PT, TT and APTT increased, and observation group PT, TT and APTT higher than the control group (P<0.05) .There were no obvious adverse reactions in the two groups during the treatment period.Conclusion The effect of calcium dobesilate capsules in the treatment of patients with DR is obvious, and it can improve hemorheology.
