Correlation between serum Galetin-3,inflammatory factors and the severity of coronary lesion and major adverse cardiac events
10.19405/j.cnki.issn1000-1492.2017.02.025
- VernacularTitle:血清半乳糖凝集素-3及炎症因子与冠脉病变程度和主要心脏不良事件的相关性
- Author:
Xiulian WANG
;
Ren ZHAO
;
Bangning WANG
- Keywords:
coronary heart disease;
Galectin-3;
Hs-CRP;
IL-6;
TNF-α;
Gensini scores
- From:
Acta Universitatis Medicinalis Anhui
2017;52(2):261-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the serum levels of Gal-3,Hs-CRP,IL-6 and TNF-α,and discuss the correlation between those indicators and the severity of coronary lesion and major adverse cardiac events( MACE). Methods Serum levels of Gal-3,Hs-CRP,IL-6 and TNF-α were detected in 126 patients with coronary heart disease and 54 patients with non-coronary heart disease. To analyze the correlation between those indicators and the severity of cor-onary lesion and MACE. Results Serum levels of Gal-3 and inflammatory factors of in the coronary heart disease group were significantly increased compared with the control group(P<0. 01),and serum levels of Gal-3 and in-flammatory factors in the multi-vessel disease group and the severe coronary disease stenosis group higer than that of the double-vessel disease group,the single-vessel disease group and the mild coronary disease stenosis group ( P<0. 05). Serum levels of Gal-3,inflammatory factors and Gensini scores were positively correlated(P<0. 01). Ser-um levels of Gal-3 , inflammatory factors were significantly higher with MACE compared to without MACE ( P <0. 05). Conclusion The serum levels of Gal-3 and Hs-CRP,IL-6,TNF-α,Gensini scores in patients with coronary heart disease are positively correlated,serum Gal-3 has great potential to become effective clinical indicators,which could be used to preliminary predict the severity of coronary artery disease and evaluate the short-term prognosis of patients with coronary heart disease.
