Clinical significance of the combined detection of 3 serum markers in early diagnosis of ovarian cancer
10.3969/j.issn.1673-4130.2017.01.026
- VernacularTitle:3种血清指标联合检测对卵巢癌早期诊断的价值
- Author:
Chen CHEN
;
Nan DAI
;
Lingjuan GAO
;
Yu ZENG
- Keywords:
ovarian cancer;
human epididymis protein 4;
carbohydrate antigens;
D-dimer
- From:
International Journal of Laboratory Medicine
2017;38(1):68-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the best cut-off value of serum human epididymis protein 4(HE4)in the diagnosis of ovarian cancer,and analyze the clinical significance of combined detection of HE4,carbohydrate antigen 125 (CA125)and D-dimer for early screening and diagnosis of ovarian cancer.Methods A total of 49 patients with ovarian cancer,63 patients with benign tumor and 47 healthy women were collected.The content of CA125,HE4 and D-dimer were detected by chemical luminescence immunoassay and turbidimetric inhibition immunoassay,respectively.Results The new cut-off value of HE4 was 54.31 pmol/L.The serum levels of HE4,CA125 and D-dimer in the ovarian cancer group were all significant higher than those in the ovarian benign tumor group and the healthy group(P＜0.05).No significant difference between the healthy group and benign disease group was found in CA125 and D-dimer content(P=0.293,0.359),while a significant difference in HE4 level(P＜0.01).The sensitivity and specificity of combined detection of the HE4+CA125 increased to 91.8％,85.4％,which was higher than that of the diagnosis detection of the three indicators respectively.The sensitivity and specificity of combined detection of the HE4 +CA125 +D-dimer were 95.0％,76.5％,which was higher than the combined detection of the HE4+CA125.Conclusion The combined detection of CA125+HE4+D-dimer could improve the sensitivity for early diagnosis and screening of ovarian cancer.
