The application of prostate specific antigen in differential diagnosis of benign and malignant prostatic tumors
10.3969/j.issn.1673-4130.2017.01.009
- VernacularTitle:血清前列腺特异性抗原对前列腺良恶性肿瘤诊断的临床应用
- Author:
Haiqiang HU
;
Xueping ZHU
;
Jie SONG
;
Huijuan PAN
;
Yuna ZHANG
- Keywords:
total prostate special antigen;
complexed prostate special antigen;
benign prostate hyperplasia;
prostate cancer
- From:
International Journal of Laboratory Medicine
2017;38(1):24-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate serum total prostate special antigen(tPSA),complexed prostate special antigen(cPSA)and cPSA/tPSA ratio(C/T) in the differential diagnosis of benign prostate hyperplasia(BPH)and prostate cancer(PCa).Methods A total of 184 serum samples from hospital outpatient and inpatient were collected from May 2009 to December 2015,and which were divided into three groups including other diseases 68 patients,benign prostate hyperplasia(BPH group)80 patients,prostate cancer (PCa group)36 patients.Chemiluminescence immunoassay was used to detect the concentration of tPSA and cPSA,and the C/T ratio were calculated in the study.Results The tPSA,ePSA levels and C/T ratio were significant different from patients with PCa,BPH and other diseases group(P＜0.01).Compared with BPH group(r=0.661),the tPSA and cPSA levels have a higher relativity in PCa group(cPSA=0.708 × tPSA-0.219,r=0.956).While when tPSA level ranges 4.0-10.0 ng/mL),no significant difference of tPSA,cPSA levels and C/T ratio were found in these 3 groups(P＞0.05).Conclusion Combined detection of serum tPSA,cPSA and C/T,making importance in the differential diagnosis of BPH and PCa.
