The prognostic value of primary tumor volume in non-endemic patients with nasopharynx carcinoma in northwest China
10.7652/jdyxb201701025
- VernacularTitle:鼻咽部肿瘤体积在中国西北非高发区鼻咽癌患者中的预后价值
- Author:
Jian ZANG
;
Man XU
;
Lina ZHAO
;
Mei SHI
- Keywords:
nasopharyngeal carcinoma;
tumor volume;
non-endemic area;
prognosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(1):117-121
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Objective To investigate the prognostic value of primary tumor volume in non-endemic patients with nasopharynx carcinoma in northwest China.Methods A total of 393 patients were enrolled in the study and all the patients had been identified with nasopharynx squamous cell carcinoma by biopsy.Overall survival (OS)and distant metastasis free survival (DMFS)were the primary endpoints.The cut-off of tumor volume was identified by ROC curves. Survival results were analyzed by the Kaplan-Meier curve. Independent prognostic factors were identified by COX proportional hazards regression model.Results The 5-year OS and DMFS for all the patients were 74.3% and 73.5%.23 mL was considered as the optimal cut-off value according to the ROC curves,and then the patients were divided into two groups (≤2 3 mL and >2 3 mL ).Patients with tumor volume ≤2 3 mL had significantly better 5-year OS and DMFS than those with tumor volume >2 3 mL (P<0 .0 5 ).The independent prognostic factors for DMFS and OS included WHO histological type,tumor volume >2 3 mL and N2-3 (P<0.05).Conclusion Primary tumor volume is an independent prognostic factor for survival of nasopharyngeal carcinoma patients in northwest China.
