Advances in differential roles of HIF-1αand HIF-2αin the pathogenesis of hypoxic pulmonary hypertension
10.3969/j.issn.1001-1978.2017.01.002
- VernacularTitle:HIF-1α和 HIF-2α在低氧性肺动脉高压中的不同作用研究进展
- Author:
Jun DENG
;
Xu ZHANG
;
Shanshan YU
- Keywords:
HIF-1α;
HIF-2α;
hypoxia;
hypoxic pulmonary hy-pertension;
regulation;
function
- From:
Chinese Pharmacological Bulletin
2017;33(1):10-13
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-induced factors(HIFs)are the main regula-tors for the response of hypoxic environment.They are involved in hypoxia-related lung tissue cell damage and abnormal cell pro-liferation,among which,HIF-1αand HIF-2αplay the most im-prominant roles.This paper reviews the current researches of HIF-1αand HIF-2α,focusing on their structural and functional similarities and diversities,as well as their roles in the patho-genesis of hypoxic pulmonary hypertension.
