Determination of Encapsulation Efficiency and Medicine Loading and Release ofβ-elemene inβ-elemene-loaded Nano Polymeric Micelles
10.3969/j.issn.1005-5304.2017.02.023
- VernacularTitle:β-榄香烯纳米聚合物胶束包封率、载药量及释药性测定
- Author:
Jing WANG
;
Xuetao LI
;
Zimin YUAN
- Keywords:
β-elemene-loaded Nano Polymeric Micelles;
encapsulation efficiency;
medicine loading;
release characteristic
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2017;24(2):91-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a RP-HPLC method for the determination of encapsulation efficiency (EE) and medicine loading (ML) in β-elemene-loaded Nano Polymeric Micelles; To study its release characteristic in vitro. Methods DSPE-PEG2000 was used as carrier to prepare medicine-loaded micelles. EE and ML were determined by petroleum ether extraction method, and its release characteristic in vitro was studied by dialysis method. Results The average EE and ML ofβ-elemene-loaded Nano Polymeric Micelles were 89.47%and 8.33%, respectively. Its release characteristic was slow. Conclusion The method for EE and ML determination is simple and accurate, and the prepared micelles have the property of sustained release.
