Diagnostic value of combined detection of serum DKK1 and EB virus VCA-IgA for nasopharyngeal car-cinoma
10.3760/cma.j.issn.1673-422X.2017.01.002
- VernacularTitle:血清DKK1和EB病毒VCA-IgA联合检测对鼻咽癌的诊断价值
- Author:
Yiwei XU
;
Lisheng HUANG
;
Haipeng GUO
;
Yuhui PENG
- Keywords:
Nasopharyngeal neoplasms;
Diagnosis;
Dickkopf-1;
EB viral capsid antigen immunoglo-bulin A
- From:
Journal of International Oncology
2017;44(1):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of the combined detection of serum Dickkopf-1 (DKK1 )and EB viral capsid antigen immunoglobulin A (VCA-IgA)in patients with nasopharyngeal carcinoma (NPC).Methods Serum levels of DKK1 and VCA-IgA were measured by enzyme-linked immunosorbent assay (ELISA)for the 80 patients with NPC and 65 normal controls.Receiver operating characteristic (ROC) curve was used to calculate the diagnostic value.Results The serum levels [M(QR )]of DKK1 in patients with NPC were significantly higher than those in normal controls [580.773 (429.1 46 )pg/ml vs.31 6.1 74 (252.965)pg/ml],with a significant difference (Z=4.846,P<0.000 1 ).ROC curves showed that the opti-mum diagnostic cutoff for serum DKK1 was 611.981 pg/ml,with an area under curve (AUC)of 0.734 (95%CI:0.654-0.81 5,50.0% sensitivity,96.9% specificity).Measurement of VCA-IgA demonstrated an AUC of 0.71 4 (95%CI:0.631-0.798,47.5% sensitivity,95.4% specificity).The combined detection of DKK1 and VCA-IgA demonstrated an AUC of 0.849 (95%CI:0.783-0.91 4,76.3%sensitivity,95.4%spe-cificity).For patients with early-stage NPC,the detection effect of combined detection of DKK1 and VCA-IgA was much better than that in normal controls,with a significant difference (χ2 =23.784,P <0.001 ). Conclusion Serum DKK1 has potential diagnostic value for NPC.Combined detection of DKK1 and VCA-IgA may aid the early diagnosis of NPC.
