Driver genes and targeted drugs in lung cancer
10.3760/cma.j.issn.1673-422X.2017.01.014
- VernacularTitle:肺癌驱动基因及其靶向治疗药物
- Author:
Yan HUANG
;
Jiyuan YANG
- Keywords:
Lung neoplasms;
Driver genes;
Targeted therapy
- From:
Journal of International Oncology
2017;44(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
With the development of molecular biology of cancer,molecular targeted therapy which tar-geted the driver genes in lung cancer has become an inevitable part of the treatment of advanced lung cancer. The most successful examples of targeted therapy are targeting epidermal growth factor receptor (EGFR)and anaplastic lymphoma kinase (ALK).More and more driver genes have been discovered,including ROS1 gene fusion,fibroblast growth factor receptor 1 amplification,KRAS,BRAF,PIK3CA gene mutation and so on.It is meaningful for guiding the treatment of lung cancer that defines the mutation incidence and clinical significance of driver genes in lung cancer.