MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2.
- Author:
Zhenshun CHENG
1
;
Rongli MA
;
Weijun TAN
;
Li ZHANG
Author Information
- Publication Type:Original Article
- MeSH: Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/pathology; Cell Movement; Cell Proliferation; Female; Fibroblast Growth Factor 2/*genetics; *Gene Expression Regulation, Neoplastic; Humans; Lung/metabolism/*pathology; Lung Neoplasms/*genetics/metabolism/pathology; Male; MicroRNAs/*genetics; Middle Aged; Neoplasm Invasiveness/genetics/pathology
- From:Experimental & Molecular Medicine 2014;46(9):e112-
- CountryRepublic of Korea
- Language:English
- Abstract: MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.
