MicroRNAs in exsomes-the new-type of regulatory molecules in the tumor progression

VernacularTitle:外泌体微小RN A--肿瘤发生发展的新型调节分子
Author: Dayang CHEN ; Fangmei AN ; Qiang ZHAN
Keywords: MicroRNAs; Neoplasm invasiveness; Neoplasm metastasis; Exsomes
From: Journal of International Oncology 2017;44(1):24-26
CountryChina
Language:Chinese
Abstract: Tumor microenvironment is the key factor that influences the invasion and metastasis of tumor cells.Exosome is the particle by which cells can make communication in microenvironment.MicroRNA (miRNA)is widely involved in physiological processes,and plays an important role in the stability of tumor environment.MiRNAs in exosome play roles in tumor cell proliferation,extracellular matrix remodeling,and then promote the metastasis,invasion and angiogenesis of tumor.Thus,the expression of oncogenes can be blocked by regulating the exosome production and secretion.It may shed light on the development of a thera-peutic strategy for tumor treatment.