Triangle relationship of PTH, intracellular calcium and CaSR in myocardial damage
10.3969/j.issn.1000-4718.2017.01.031
- VernacularTitle:PTH、细胞内钙和 CaSR 在心肌损伤中的“三角关系”
- Author:
Xing LUO
;
Changqing XU
- Keywords:
Parathyroid hormone;
Intracellular calcium;
Calcium-sensing receptor;
Myocardial damage
- From:
Chinese Journal of Pathophysiology
2017;33(1):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Parathyroid hormone ( PTH) is an important hormone secreted by parathyroid cells , and regulates the metabolism of calcium and phosphorus in the body .In recent years , the toxic effect of PTH on myocardium has been re-ported.Calcium-sensing receptor (CaSR), a member of G protein-coupled receptor family, can feel the subtle change of extracellular calcium concentration and regulate intracellular calcium concentration through multifarious ways in order to control the secretion of PTH .The expression of CaSR is observed in parathyroid cells , renal tubular epithelial cells , myo-cardial cells, etc.Intracellular calcium, as a second messenger, participates in various cell functions , such as excitation-contraction coupling , fertilization and so on .The injury of myocardial cells is intimately linked with high concentrations of PTH and intracellular calcium , and high expression of CaSR .
