Research progress on pacemaker function of interstitial cells of Cajal in gastrointestinal tract

VernacularTitle:胃肠道Cajal间质细胞起搏功能的研究进展
Author: Jianhai CHEN ; Jie ZHONG ; Fan WANG ; Guimei KONG ; Xiaoyun DONG ; Haihang ZHU ; Ping BU
Keywords: Interstitial cells of Cajal; Pacemaking mechanism; Ion channel
From: Chinese Journal of Pathophysiology 2017;33(1):184-188
CountryChina
Language:Chinese
Abstract: [ ABSTRACT] Interstitial cells of Cajal ( ICC) is the pacemaker in the gastrointestinal tract , which is closely as-sociated with the formation of slow wave and the regulation of gastrointestinal motility .As the pacemaker of gastrointestinal tract, the activation of pacing signal is triggered by the local calcium oscillation in the ICC .The change of calcium concen-tration can activate many relevant ion channels , such as NSCC, ANO1, VGCC, HCN channels and potassium channels , which can generate a large number of pacing current to form the slow wave and then propagated by the gap junction between the ICC networks and smooth muscle cells to make the peristalsis of gastrointestinal tract in autonomic rhythm .However, the mechanism of these ion channels in the pacemaker activity is still unclear , so we refer to make a review about the re-search progress on these pacemaker channels in this article to illuminate the mechanism of pacemaker activity in ICC .