Research advances of PI 3 K/Akt/mTOR signaling pathway with its related gene mutations and the targeted therapy for endometrial cancer
- VernacularTitle:PI3K/Akt/mTOR信号通路及其相关基因突变与子宫内膜癌靶向性药物治疗的研究进展
- Author:
Chuchu CAO
;
Luren HUANG
;
Fen FU
- Keywords:
the PI3K/Akt/mTOR signaling pathway;
gene mutations;
endometrial cancer;
targeted therapy
- From:
Basic & Clinical Medicine
2017;37(1):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Endometrial cancer ( EC) is one of the most common gynecological cancer ,of which the molecular biolog-ical mechanisms is very complex .In recent years, it has been reported that the abnormally regulated PI 3K/Akt/mTOR signaling pathway is significantly related with endometrial cancer .The mutation and abnormal activation of the receptors and kinase of the PI 3 K/Akt/mTOR signaling pathway is a potential therapeutic target of endometrial cancer .