Progress in encephalopathy of prematurity
10.3760/cma.j.issn.1673-4408.2016.12.002
- VernacularTitle:早产儿脑病的研究进展
- Author:
Na LIU
;
Zhiyong LI
;
Jianhua FU
- Keywords:
Encephalopathy of prematurity;
Premyelinating oligodendrocyte;
Neuron;
Dysmaturation
- From:
International Journal of Pediatrics
2016;43(12):909-912
- CountryChina
- Language:Chinese
-
Abstract:
With the increased survival of the low birth weight,brain injury in the premature infants be-comes a problem of enormous importance. The introduction of the term “encephalopathy of prematurity” is the current recognition that preterm brain injury is a complex of white and gray matter damage. The combination of white matter injury and neuronal/axonal deficits constitutes encephalopathy of prematurity. The preterm infants develop primary destructive brain lesions,secondary degeneration and disturbance of maturation from hypoxia-is-chemia and inflammation,which leads to cerebral palsy,cognitive,behavioral,or language deficits. This article reviews the neuropathology,pathogenesis,therapy and neurodevelopmental disability of encephalopathy of pre-maturity.
