Gut microbiota and type 2 diabetes
10.3760/cma.j.issn.1000-6699.2016.12.014
- VernacularTitle:肠道菌群与2型糖尿病研究现状及进展
- Author:
Liping XUAN
;
Min XU
;
Ruixin LIU
;
Yufang BI
;
Guang NING
;
Weiqing WANG
- Keywords:
Diabetes mellitus,type 2;
Gut microbiota;
Prebiotic;
Fecal microbiota transplantation
- From:
Chinese Journal of Endocrinology and Metabolism
2016;32(12):1041-1044
- CountryChina
- Language:Chinese
-
Abstract:
Recently, gut microbiota is found to be associated with human health and diseases. Environmental and genetic factors both play pivotal roles in the pathogenesis of type 2 diabetes, in which the gut microbiota is regarded as an important environmental factor. In addition, gut microbiota may become a novel therapeutic approach for type 2 diabetes. Present review focused on the association between the alterations of gut microbiome and type 2 diabetes, hyperglycemia, and insulin resistance;also summarized the molecular mechanisms underlying microbe-host interactions in the context of diabetes, potential contribution of the gut microbiota to the pharmacological or surgical treatment of type 2 diabetes, and the interaction of human genetics with gut microbiome. Based on the understanding of gut microbiota-host interactions, probiotic and fecal microbiota transplantation will be potential novel therapeutic approaches for type 2 diabetes.
