Correlation between protein C and Legg -Calve -Perthes disease:a Meta-analysis
10.3760/cma.j.issn.2095-428X.2016.23.015
- VernacularTitle:蛋白C与儿童股骨头缺血性坏死相关性的Meta分析
- Author:
Huaijing YU
;
Song YU
;
Zheng XIAO
;
Juan LI
;
Yifa JI
;
Yongqiao GAN
;
Kai SU
;
Xing ZHAO
- Keywords:
Legg -Calve -Perthes disease;
Protein C;
Meta -analysis;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2016;31(23):1817-1821
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the association between protein C and Legg -Calve -Perthes disease.Methods A literature research was performed through PubMed,Embase,Cochrane library,Web of Science,Chinese Biomedical Literature Database(CBM),China National Knowledge Infrastructure(CNKI)and Wan-fang Database from inception to February 201 6 on the association between protein C and Legg -Calve -Perthes disease.According to the Newcastle -Ottawa Scale(NOS)criteria,the quality of studies was evaluated and data were extracted.Meta -analysis was performed with Stata 1 1 .0 software.Results A total of 1 4 articles were included.Twelve articles on protein C and Legg -Calve -Perthes disease in the study group and the control group were compared.The results of Meta -analysis showed that there was no significant difference in protein C levels between the study group and the control group[odds radio(OR)=1 .41 ,95% confidence interval(CI)(0.87,2.28),P =0.1 47];five articles on protein C and the white race of Legg -Calve -Perthes disease between the study group and the control group were com-pared,The results of Meta -analysis showed that there was no significant difference in protein C levels between the whiteskin patients′group and the control group[OR =0.61 2,95%CI(1 .83,7.29),P =0.61 2];three articles on pro-tein C and the yellow race of Legg -Calve -Perthes disease between the study group and the control group were com-pared,and the results of Meta -analysis showed that there was no significant difference in protein C levels between the yellow skin patients group and the control group[OR =0.59,95%CI(0.05,6.72),P =0.080].Conclusion There is no significant correlation between protein C and Legg -Calve -Perthes disease.
